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The National
Cancer Institute will has awarded $10.5 million in funding
to three Seattle research centers to study genes and proteins
that make prostate cancer cells virulent and stimulate their
spread into human bone.
The five-year
project grant, called "Mechanisms and Markers of Prostate
Metastases," was awarded to the University of Washington,
the Fred Hutchinson Cancer Research Center and the Institute
for Systems Biology.
Previous
studies at the University of Washington have determined that
many men -- even those subsequently cured with local therapy
-- appear to have prostate cancer cells in their blood and
bone marrow very early in the disease process.
Researchers
will seek to learn why some of these cells turn into deadly
metastatic cancer, while others remain dormant or die.
The researchers
plan to use new tools from bone and cancer biology, cancer
endocrinology, biochemistry and genomics to study the mechanisms
of prostate cancer growth.
"The
program project grant is further evidence that Seattle has
become a major center of prostate research," said Dr.
Paul Lange, chair of the University of Washington Department
of Urology and himself a prostate cancer survivor.
Source:
Prostate Cancer
Week of July 21, 2002
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