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Vitamin
A and its natural and synthetic derivatives called retinoids
have been shown to have a protective effect against tobacco-caused
lung cancer but this effect is suppressed by nicotine, according
to researchers at the Burnham Institute in La Jolla, California.
Researchers
analyzed human lung cancer cells that were treated with a
variety of retinoids and found that nicotine inhibited the
protective action of the retinoids, according to the study
published in the International Journal of Cancer.
Researchers
concluded that the inhibition of retinoid activity by nicotine
may contribute to the lack of effectiveness of retinoids in
cigarette smokers. They also found that some retinoids may
be more effective than others in preventing tobacco-linked
cancers.
Source:
Medical Week staff,
week of May 19, 2002
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