Advanced heart failure patients
with diabetes who are treated with insulin face a mortality rate four times
higher than heart failure patients with diabetes treated with oral medications, according to UCLA researchers.
Results of the new study, reported in the January issue of the American Heart Journal, may help raise awareness among physicians and patients of this previously unknown relationship between insulin use and increased mortality in advanced heart failure patients.
More research is needed to explore the mechanisms of how insulin use may be contributing to the higher mortality rate, the researchers said.
Previous studies have shown a connection between type 2 diabetes, heart failure and insulin, but the UCLA study is the first to identify a high mortality rate for advanced heart failure patients who use insulin to manage diabetes.
"Further studies into what is the best strategy to control blood sugar levels in patients with diabetes and heart failure are urgently needed," said Dr. Gregg Fonarow, professor of cardiology
and the lead researcher in the study.
Researchers assessed the history of diabetes and insulin treatment in 554 patients with advanced heart failure after adjusting for various risk factors. One year survival rates were 89.7 percent for non-diabetic patients, 85.8 percent for non-insulin-treated diabetic patients, and only 62.1 percent for insulin-treated diabetic patients.
Heart failure affects 5 million in the United States and is the most common cause of hospitalization for those 65 years and older. Between 25 to 44 percent of heart failure patients also have diabetes
Source:
Medical Week staff,
Dec. 30, 2004
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