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Senior Health Week: Acid Reflux - Ulcers
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Acid Reflux - Ulcer News:

Aciphex® and Antibiotics Clear up H. Pylori Infections in Seven Days

A combination of the proton pump inhibitor Aciphex® (rabeprazole sodium) and antibiotics appears to clear up infections with H. pylori, the most common cause of peptic ulcers, in seven days as effectively as a 10-day treatment with Prilosec® (omeprazole) and antibiotics, according to researchers.

A study, conducted at 47 centers nationwide, looked at 803 patients infected with H. pylori (Helicobacter pylori). Approximately half of the patients had either an active peptic ulcer or a history of the disease.

The patients were treated with either three days of rabeprazole, amoxicillin and clarithromycin (RAC); seven days of RAC; ten days of RAC; or 10 days of omeprazole, amoxicillin and clarithromycin (OAC). The goal of the study was to see whether three-, seven- or ten-day RAC treatment was as effective as 10-day treatment with OAC in eradicating H. Pylori.

Eighty-four percent of the patients treated with rabeprazole, amoxicillin and clarithromycin were free of H. pylori after seven days of treatment and 86 percent were cleared in 10 days. Eighty-two percent of the patients given omeprazole, amoxicillin and clarithromycin were free of H. pylori after ten days.

The three-day Aciphex, amoxicillin and clarithromycin treatment was not proven effective.

Source: Medical Week staff, week of May 12, 2002


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