of the proton pump inhibitor Aciphex® (rabeprazole sodium)
and antibiotics appears to clear up infections with H. pylori,
the most common cause of peptic ulcers, in seven days as effectively
as a 10-day treatment with Prilosec® (omeprazole) and
antibiotics, according to researchers.
conducted at 47 centers nationwide, looked at 803 patients
infected with H. pylori (Helicobacter pylori). Approximately
half of the patients had either an active peptic ulcer or
a history of the disease.
were treated with either three days of rabeprazole, amoxicillin
and clarithromycin (RAC); seven days of RAC; ten days of RAC;
or 10 days of omeprazole, amoxicillin and clarithromycin (OAC).
The goal of the study was to see whether three-, seven- or
ten-day RAC treatment was as effective as 10-day
treatment with OAC in eradicating H. Pylori.
percent of the patients treated with rabeprazole, amoxicillin
and clarithromycin were free of H. pylori after seven days
of treatment and 86 percent were cleared in 10 days. Eighty-two
percent of the patients given omeprazole, amoxicillin and
clarithromycin were free of H. pylori after ten days.
Aciphex, amoxicillin and clarithromycin treatment was not
Medical Week staff,
week of May 12,